Content Tagged with: Declan McCole

Novel mechanism links genetic defect in IBD patients to gut leakiness

A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier. The intestinal epithelium, a...

By Iqbal Pittalwala | | Health

Drug found to correct gene defect that causes immune-driven gut leakiness

UC Riverside-led study is the first to show how tofacitinib rescues gut barrier function from overactive immune cells

By Iqbal Pittalwala | | Health

Understanding a gene’s role in inflammatory bowel disease

UC Riverside mouse study will identify mechanisms the gene PTPN2 uses to affect gut cells

By Iqbal Pittalwala | | Health

Drug decreases gut leakiness associated with ulcerative colitis

UC Riverside-led study is the first to show how tofacitinib affects epithelial cells lining the gut

By Iqbal Pittalwala | | Health

Space travel can make the gut leaky

UC Riverside-led study tested the effects of microgravity on intestinal epithelial cells

By Iqbal Pittalwala | | Health